Mama Shelter Prague offers a unique experience of a ten floors hotel situated close to the main attractions, to a large park and to the Prague Holešovice exhibition grounds. The hotel offers 238 rooms designed by Jalil Amor; rooms are as comfortable as they are smart, featuring Mama Skin organic solid amenities, free movies, and smart screens. There are also two large restaurants, two lively bars, and a lot of space for informal meetings.
The easiest way to get to the hotel from the airport is by TrolyBus #59 to Metro Line A station Nádraží Veleslavín, going by Metro by station Staroměstská, and then taking tram #17 to stop Veletržní palác (total travel time is about 45 minutes, the fare is 40 CZK, tariff 90 minutes).
Please note, that due to repairs to the 2nd road in front of Terminal 1 of Prague Airport, there are changes regarding public transport stops. More information can be found at https://www.prg.aero/en/public-transport-buses and https://www.prg.aero/en/oprava-komunikace-u-terminalu-1-jaka-dopravni-omezeni-prinese
Excellent Prague Public Transport (MHD) is provided by Metro (subway), trams, and buses from 5 a.m. till midnight, and by night trams (non-stop). Tickets can be bought in yellow sales machines (at the airport, in each Metro station) or at newsstands for CZK 40 (valid transfer 90 minutes ticket) or CZK 30 (non-transferable tickets valid 30 minutes). A day card can be also purchased.
More information including network maps, timetables, and journey planner can be found there. Also IDOS is very popular and useful web page and application to get around Prague.
Don't forget to buy a 40 CZK ticket from the news-stand or from the yellow machine at the airport.